Prediction of response to chemotherapy in acute myelocytic leukemia
نویسندگان
چکیده
منابع مشابه
Prediction of response to chemotherapy in acute myelocytic leukemia.
Marrow specimens obtained from 23 patients with acute myelocytic leukemia were exposed to cytosine arabinoside and/or daunorubicin in vitro, and the effects of these agents on colony formation in vitro was determined. Thymidine suicide indices were determined as well, which permitted a distinction to be made between kinetic and metabolic resistance to cytosine arabinoside. The sensitivity of th...
متن کاملChemotherapy of acute myelocytic leukemia in children.
Acute myelocytic leukemia (AML) in both children and adults is a more complex and resistant disease than acute lymphocytic leukemia. Progress has been slower and therapy more complicated, but with intensive myelosuppressive induction and further postremission therapy one-third of such patients may now achieve longterm survival and probably be cured.’-5 In the Nordic countries (Denmark, Finland,...
متن کاملPrediction of Response to Chemotherapy in Acute
Marrow specimens obtained from 23 patients with acute myelocytic leukemia were exposed to cytosine arabinoside and/or daunorubicin in vitro, and the effects of these agents on colony formation in vitro was determined. Thymidine suicide indices were determined as well, which permitted a distinction to be made between kinetic and metabolic resistance to cytosine arabinoside. The sensitivity of th...
متن کاملCorrelation Between Soluble Vascular Endothelial Growth Factor A, Its Receptor 1 And Response To Chemotherapy In Acute Leukemia In Children
Background and Objective: Vascular endothelial growth factor (VEGF) and its receptors (VEGF-R1 and R2) are major regulators of angiogenesis. This study was designed to assess serum levels of VEGF and VEGF-R1 and their prognostic significance in newly diagnosed childhood acute leukemia. Materials and Methods: For this purpose, VEGF and VEGF-R1 were determined using enzyme linked immuno-sorba...
متن کاملDaunorubicin metabolism in acute myelocytic leukemia.
mic enzyme that converts daunorubicm to a principal metabolite, daunorubicino!, in the presence of NADPH. This enzyme, found in mammalian tissues and studied in rat tissue preparations and normal human blood components, is also present in human leukemic myeloblasts. The enzymes from both normal and leukemic leukocytes require NADPH for activity, have similar kinetics and substrate saturation ch...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Blood
سال: 1980
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v56.3.361.361